D various forms of GBS infection of the urinary tract have
PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28549178 However, the relative significance of ABU due to GBS in pregnancy compared to that due to other Cenicriviroc custom synthesis organisms remains unclear [23,24]. MedChemExpress BAY1217389 Typically, s-QBC ranging between 103 and 105 CFU/ml are used for laboratory-based prediction of acute uncomplicated UTI in symptomatic patients. The aim of this study was to investigate the prognostic value of s-QBC in the diagnosis of acute GBS UTI in the setting of adult patients with urine cultures positive for this organism. We retrospectively analyzed data for the largest cohort of patients described to date in order to examine whether s-QBC is useful as a predictor of acuteGBS UTI independent of other variables. The findings show that s-QBC is not useful in the prediction of infection category, and suggest that age-based associations may be equally as valuable compared to s-QBC for the differential diagnosis of acute UTI and ABU due to GBS. This study represents the first analysis of the role of s-QBC in the diagnosis of GBS UTI, and despite some limitations, the findings reported here provide useful new insight into the interpretation of s-QBC values for GBS UTI.MethodsStudy designThis study was conducted using clinical and laboratory data from a single-center analysis of GBS UTI in patients at University of Alabama at.D various forms of GBS infection of the urinary tract have been described in subsequent studies [10-14]. While generally associated with maternal cervicovaginal colonization and neonatal disease, GBS also frequently causes serious infections including acute UTI in older persons and those with chronic medical illness [15,16]. The spectrum of GBS UTI encompasses asymptomatic bacteruria (ABU), cystitis, pyelonephritis, and urosepsis. Clinically, acute GBS UTI is indistinguishable from acute UTI caused by other uropathogenic bacteria, and diagnosis is made difficult by high rates of sample contamination and asymptomatic infection [14,17]. GBS is cultured from urine in approximately 2 of all cases of clinically suspected UTI [10,14,18,19]. In addition, urinary GBS complicates up to 7 of pregnancies and contributes up to 10 of cases of pyelonephritis in pregnancy [17,19-21]. GBS ABU is considered particularly important during pregnancy due to the risk of vertical transmission of the organism, which mandates antibiotic therapy . PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28549178 However, the relative significance of ABU due to GBS in pregnancy compared to that due to other organisms remains unclear [23,24]. Diagnostic strategies and use of the recommended treatment guidelines for bacterial UTI varies substantially between clinicians [25-28]. A combination of symptoms in adults is considered predictive with a high degree of probability for acute infection [29,30], however, there can be difficulties in applying general rules to specific patient populations such as the elderly . In the laboratory setting, semi-quantitative bacteruria PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/26931637 counts (s-QBC) are routinely used as a diagnostic criterion for individuals suspected of having a UTI. Typically, s-QBC ranging between 103 and 105 CFU/ml are used for laboratory-based prediction of acute uncomplicated UTI in symptomatic patients. However, there exists debate on the interpretation of s-QBC for diagnostic criteria, and revisions of the traditionally accepted 105 CFU/ml cut-off value for acute UTI have emerged.